Optimizing HVAC Design for Pharmaceutical Requirements with Computational Fluid Dynamics
Publication: Computing in Civil Engineering 2023
ABSTRACT
The conventional design process of pharmaceutical clean rooms is typically based on 2D CAD drawings, which can rarely generate simulation models of temperature distribution to verify the effectiveness of HVAC systems. Such design process is likely to cause errors in the operation stage, eventually failing the design requirements. To address the design challenges in pharmaceutical projects, this paper presents a BIM-based approach to optimize HVAC design with computational fluid dynamics (CFD). By utilizing CFD to simulate the dynamic conditions of airflow in clean rooms, the effectiveness of HVAC systems can be verified. A case study of a typical clean room design is presented to demonstrate the workflow of the approach and validate its functionalities. The results of the case study have shown that CFD can successfully simulate the design intentions of indoor air quality in BIM models and suggest optimized HVAC systems for clean room design. The findings of this paper contribute to the body of knowledge on overcoming the limitations of the traditional CAD-based HVAC design process and provide valuable insights on optimizing HVAC design with BIM and CFD technologies.
Get full access to this article
View all available purchase options and get full access to this chapter.
REFERENCES
Cui, W., Yang, Q., and Zhu, Y. (2014). “Field study of thermal environment spatial distribution and passenger local thermal comfort in aircraft cabin.” Build. Environ., 80, 213–220.
Du, H., Lian, Z., Lai, D., Duanmu, L., Zhai, Y., Cao, B., Zhang, Y., and Zhou, X. (2022). “Comparison of thermal comfort between radiant and convective systems using field test data from the Chinese Thermal Comfort Database.” Build. Environ., 209. 108685.
Fanger, P. O. (1967). “Calculation of thermal comfort-introduction of a basic comfort equation.” ASHRAE Trans, 73, III4.1–III4.20.
Gao, N., Niu, J., and Zhang, H. (2006). “Coupling CFD and human body thermoregulation model for the assessment of personalized ventilation.” HVAC&R Res., 12(3), 497–518.
Geng, Y., Ji, W, Lin, B., and Zhu, Y. (2017). “The impact of thermal environment on occupant IEQ perception and productivity.” Build. Environ., 121, 158–167.
Li, M., Li, F., Jing, Y., Zhang, K., Cai, H., Chen, L., Zhang, X., and Feng, L. (2022). “Estimation of pollutant sources in multi-zone buildings through different deconvolution algorithms.” Building Simulation, 15, 817–830.
Liu, W., Zhang, T., Xue, Y., Zhai, Z. J., Wang, J., Wei, Y., and Chen, Q. (2015). “State-of-the-art methods for art methods for inverse design of an enclosed environment.” Build. Environ., 91, 91–100.
Martins, L. A., Soebarto, V., and Williamson, T. (2022). “A systematic review of personal thermal comfort models.” Build. Environ., 207, 108502.
Pernigotto, M., Tarantini, G., and Gasparella, A. (2017). “A co-citation analysis on thermal comfort and productivity aspects in production and office buildings.” Buildings, 7(2), 36.
Pombeiro, H., Machado, M. J., and Silva, C. (2017). “Dynamic programming and genetic algorithms to control an HVAC system: Maximizing thermal comfort and minimizing cost with PV production and storage.” Sustainable Cities Soc., 34, 228–238.
Satrio, P., Mahlia, T. M. I., Giannetti, N., and Saito, K. (2019). “Optimization of HVAC system energy consumption in a building using artificial neural network and multi-objective genetic algorithm.” Sustain. Energy Technol. Assess., 35, 48–57.
Tanabe, S. I., Kobayashi, K., Nakano, J., Ozeki, Y., and Konishi, M. (2002). “Evaluation of thermal comfort using combined multi-node thermoregulation (65mn) and radiation models and computational fluid dynamics (CFD).” Energy Build., 34(6), 637–646.
Wang, X., Zhao, J., Wang, F., Song, B., and Zhang, Q. (2021). “Air supply parameter optimization of a custom nonuniform temperature field based on the POD method.” Build. Environ., 206, 108328.
Yakhot, V., and Orszag, S. A. (1986). “Renormalization group analysis of turbulence. I. Basic theory.” J. Sci. Comput., 1(1), 3–51.
Zhang, T., Liu, Y., Rao, Y., Li, X., and Zhao, Q. (2020). “Optimal design of building environment with hybrid genetic algorithm, artificial neural network, multivariate regression analysis and fuzzy logic controller.” Build. Environ., 175, 106810.
Zhang, Z., Zhang, W., Zhai, Z. J., and Chen, Q. Y. (2007). “Evaluation of various turbulence models in predicting airflow and turbulence in enclosed environments by CFD: Part 2-Comparison with experimental data from literature.” HVAC&R Res., 13(6), 871–886.
Zhao, X., and Yin, Y. (2022). “Inverse regulation of the indoor environment: An overview of the adjoint method.” Energy Build., 259, 111907.
Zhao, X., Yin, Y., He, Z., and Liu, X. (2021). “Inverse design of indoor radiant terminal using the particle swarm optimization method with topology concept.” Build. Environ., 204, 108117.
Zhou, K., Li, F., Cai, H., Jing, Y., Zhuang, J., Li, M., and Xing, Z. (2022). “Estimation of the natural gas leakage source with different monitoring sensor networks in an underground utility tunnel from the perspectives of energy security.” Energy Build., 254, 111645.
Information & Authors
Information
Published In
History
Published online: Jan 25, 2024
ASCE Technical Topics:
- Architectural engineering
- Building design
- Building systems
- Case studies
- Computational fluid dynamics technique
- Computer aided design
- Computer models
- Design (by type)
- Engineering fundamentals
- Fluid dynamics
- Fluid mechanics
- HVAC
- Hydrologic engineering
- Methodology (by type)
- Models (by type)
- Optimization models
- Research methods (by type)
- Simulation models
- Two-dimensional models
- Water and water resources
Authors
Metrics & Citations
Metrics
Citations
Download citation
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.