Analytical Methods Used to Measure Endocrine Disrupting Compounds in Water
Publication: Practice Periodical of Hazardous, Toxic, and Radioactive Waste Management
Volume 7, Issue 4
Abstract
Endocrine-disrupting compounds (EDCs) have been detected in natural waters globally. Additionally, trace concentrations of pharmaceuticals and personal care products (PPCPs) have also been detected in various waters, primarily as the result of incomplete wastewater treatment. Some PPCPs are known to act as EDCs as they can have impacts on the endocrine systems of animals. The detection of EDCs and PPCPs in source water is of great concern since some of these compounds have known physiological responses at low concentrations. The majority of EDCs and PPCPs are more polar than traditional contaminants, such as polychlorinated biphenyls and organochlorine pesticides, and several have acidic or basic moieties. These properties, coupled with trace quantities, create unique challenges for both removal processes and analytical detection. There are two general approaches for monitoring EDCs and PPCPs in water: (1) direct measurement of target compounds via analytical instrumentation and (2) biological assays. These approaches will be discussed with an emphasis on analytical methods for direct measurements.
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References
Aherne, G. W., English, J., and Marks, V.(1985). “The role of immunoassay in the analysis of microcontaminants in water samples.” Ecotoxicol. Environ. Saf., 9, 79–83.
Anderson, M. J., Miller, M. R., and Hinton, D. E.(1996). “In vitro modulation of 17-b estradiol-induced vitellogenin synthesis: Effects of cytochrome P4501A1 inducing compounds on rainbow trout (Onchorhynchus mykiss) liver cells.” Aquat. Toxicol.,34, 327–350.
Behnisch, P. A., Fujii, K., Shiozaki, K., Kawakami, I., and Sakai, S.(2001). “Estrogenic and dioxin-like potency in each step of a controlled landfill leachate treatment plant in Japan.” Chemosphere, 43(4–7), 977–984.
Bennett, E. R., and Metcalfe, C. D.(2000). “Distribution of degradation products of alkylphenol ethoxylates near sewage treatment plants in the lower great lakes, North America.” Environ. Toxicol. Chem., 19(4), 784–792.
Bennie, D. T., Sullivan, C. A., Lee, H. B., Peart, T. E., and Maguire, R. J.(1997). “Occurrence of alkylphenols and alkylphenol mono- and diethoxylates in natural waters of the Laurentian Great Lakes basin and the upper St. Lawrence River.” Sci. Total Environ., 193, 263–275.
Bevans, H. E., Goodbred, S. L., Miesner, J. F., Watkins, S. A., Gross, T. S., Denslow, N. D., and Schoeb, T. (1996). “Synthetic organic compounds and carp endocrinology and histology in Las Vegas wash and Las Vegas and Callville Bays of Lake Mead, Nevada, 1992 and 1995.” Water-Resources Investigations Rep., U.S. Geological Survey, Washington, D.C., 96–4266.
Blanchard, M., Teil, M. J., Ollivon, D., Garban, B., Chesterikoff, C., and Chevreuil, M.(2001). “Origin and distribution of polyaromatic hydrocarbons and polychlorobiphenyls in urban effluents to wastewater treatment plants of the Paris area (France).” Water Res., 35(15), 3679–3687.
Bortone, S. A., and Davis, W. P.(1994). “Fish intersexuality as indicator of environmental stress.” BioScience, 44(3), 165–172.
Bryan, G. W., Gibbs, P. E., and Burt, G. R.(1988). “A comparison of the effectiveness of tri-n-butyltin chloride and five other organotin compounds in promoting the development of imposex in the dog-whelk, Nucella lapillus.” J. Mar. Biol. Assoc. U.K., (68), 733–744.
Buser, H. R., Muller, M. D., and Theobald, N.(1998a). “Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North Sea.” Environ. Sci. Technol., 32(1), 188–192.
Buser, H. R., Poiger, T., and Muller, M. D.(1998b). “Occurrence and fate of the pharmaceutical drug diclofenac in surface waters: Rapid photodegradation in a lake.” Environ. Sci. Technol., 32(22), 3449–3456.
Buser, H. R., Poiger, T., and Muller, M. D.(1999). “Occurrence and environmental behavior of the chiral pharmaceutical drug ibuprofen in surface waters and in wastewater.” Environ. Sci. Technol., 33(15), 2529–2535.
Byrns, G.(2001). “The fate of xenobiotic organic compounds in wastewater treatment plants.” Water Res., 35(10), 2523–2533.
Carlile, P., Fielding, M., Harding, L., Hart, J., Hutchison, J., and Kanda, R. (1996). “Effect of water treatment processes on oestrogenic chemicals.” UK WIR Rep. 96/DW/05/01, United Kingdom Water Industry Research Limited (UKWIR), London.
Daughton, C. G., and Ternes, T. A.(1999). “Pharmaceuticals and personal care products in the environment: Agents of subtle change?” Environ. Health Perspect., 107(6), 907–938.
David, B., and Riguier, D.(2002). “Ultrasonication of aqueous and micellar suspensions of anthracene fixed on silica.” Ultrason. Sonochem., 9(1), 45–52.
Day, J. A., Vonderheide, A., Caruso, J. A., and Gluodenis, T. J. J. (2001). “Automated real-time determination of bromate in drinking water using LC-ICP-MS and EPA Method 321.8.” Univ. of Cincinnati, Cincinnati.
Desbrow, C., Routledge, E. J., Brighty, G. C., Sumpter, J. P., and Waldock, M.(1998). “Identification of estrogenic chemicals in STW effleunt. I: Chemical fractionation and in vitro biological screening.” Environ. Sci. Technol., 32(11), 1549–1558.
Diemer, J., and Heumann, K. G.(1997). “Bromide/bromate speciation by NTI-IDMS and ICP-MS coupled with ion exchange chromatography.” Fresenius J. Anal. Chem., 357, 74–79.
Echols, K. R., Gale, R. W., Schwartz, T. R., Huckins, J. N., Williams, L. L., Meadows, J. C., Morse, D., Petty, J. D., Orazio, C. E., and Tillitt, D. E.(2000). “Comparing polychlorinated biphenyl concentrations and patterns in the Saginaw River using sediment, caged fish, and semipermeable membrane devices.” Environ. Sci. Technol., 34(19), 4095–4102.
Edwards, M.(1994). “Chemistry of arsenic removal during coagulation and Fe-Mn oxidation.” J. Am. Water Works Assoc., 86(9), 64–74.
Fallon, J. D., Tierney, D. P., and Thurman, E. M.(2002). “Movement of atrazine and deethylatrazine through a midwestern reservoir.” J. Am. Water Works Assoc., 94(11), 54–66.
Fatoki, O. S., and Awofolu, R. O.(2003). “Methods for selective determination of persistent organochlorine pesticide residues in water and sediments by capillary gas chromatography and electron-capture detection.” J. Chromatogr. A, 983(1–2), 225–236.
Fawell, J. K., Sheahan, D., James, H. A., Hurst, M., and Scott, S.(2001). “Oestrogens and oestrogenic activity in raw and treated Severn Trent water.” Water Res., 35(5), 1240–1244.
Field, J. A., and Reed, R. L.(1996). “Nonylphenol polyethoxy carboxylate metabolites of nonionic surfactants in U.S. paper mill effluents, municipal sewage treatment plant effluents, and river waters.” Environ. Sci. Technol., 30(12), 3544–3550.
Fielding, M., Harding, L., James, C., and Mole, N. (1998). “Removal of nonylphenol ethoxylates by water treatment processes.” UK WIR Rep. 98/TX/01/5, United Kingdom Water Industry Research Limited (UKWIR), London.
Fischer, T. P., Hilton, D. R., Zimmer, M. M., Shaw, A. M., Sharp, Z. D., and Walker, J. A.(2002). “Subduction and recycling of nitrogen along the central American margin.” Science, 297(5584), 1154–1157.
Folmar, L. C., Denslow, N. D., Rao, V., Chow, M., Crain, D. A., Enblom, J., Marcino, J., and Guillette, Jr., L. J.(1996). “Vitellogenin induction and reduced serun testosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant.” Environ. Health Perspect., 104(10), 1096–1101.
Folmar, L. C., Hemmer, M. J., Denslow, N. D., Kroll, K., Chen, J., Cheek, A., Richman, H., Meredith, H., and Grau, E. G.(2002). “A comparison of the estrogenic potencies of estradiol, ethynylestradiol, diethylstilbestrol, nonylphenol and methoxychlor in vivo and in vitro.” Aquat. Toxicol. ,60(1–2), 101–110.
Giesy, J. P., Hilscherova, K., Jones, P. D., Kannan, K., and Machala, M.(2002). “Cell bioassays for detection of aryl hydrocarbon (AhR) and estrogen receptor (ER) mediated activity in environmental samples.” Mar. Pollution Bull., 45(1–12), 3–16.
Giesy, J. P., Pierens, S. L., Snyder, E. M., Miles-Richardson, S., Kramer, V. J., Snyder, S. A., Nichols, K. M., and Villeneuve, D. A.(2000). “Effects of 4-nonylphenol on fecundity and biomarkers of estrogenicity in fathead minnows (Pimephales promelas).” Envir. Toxicol. Chem., 19(5), 1368–1377.
Gimeno, S., Komen, H., Venderbosch, P. W. M., and Bowmer, T.(1997). “Disruption of sexual differentiation in genetic male common carp (Cyprinus carpio) exposed to an alkylphenol during different life stages.” Environ. Sci. Technol., 31, 2884–2890.
Grange, A. H., and Brumley, W. C.(1997). “A mass peak profile generation model to facilitate determination of elemental compositions of ions based on exact masses and isotopic abundances.” J. Am. Soc. Mass Spectrom., 8, 170–182.
Grange, A. H., Donnelly, J. R., Sovocool, G. W., and Brumley, W. C.(1996). “Determination of elemental compositions from mass peak profiles of the molecular ion (M) and the M+1 and M+2 ions.” Anal. Chem., 68(3), 553–560.
Gray, M. A., and Metcalfe, C. D.(1997). “Induction of testis-ova in Japanese medaka (Oryzias latipes) exposed to p-nonylphenol.” Environ. Toxicol. Chem., 16(5), 1082–1086.
Gray, L. E., Ostby, J., Wilson, V., Lambright, C., Bobseine, K., Hartig, P., Hotchkiss, A., Wolf, C., Furr, J., Price, M., Parks, L., Cooper, R. L., Stoker, T. E., Laws, S. C., Degitz, S. J., Jensen, K. M., Kahl, M. D., Korte, J. J., Makynen, E. A., Tietge, J. E., and Ankley, G. T.(2002). “Xenoendocrine disrupters-tiered screening and testing filling key data gaps.” Toxicology, 181–182, 371–382.
Harries, J. E., Sheahan, D. A., Jobling, S., Matthiessen, P., Neall, P., Sumpter, J. P., Tylor, T., and Zaman, N.(1997). “Estrogenic activity in five United Kingdom rivers detected by measurement of vitellogenesis in caged male trout.” Environ. Toxicol. Chem., 16(3), 534–542.
Hirsch, R., Ternes, T. A., Bobeldijk, I., and Weck, R. A.(2001). “Determination of environmentally relevant compounds using fast GC/TOF-MS.” Chimia, 55(1–2), 19–22.
Hohenwarter, O., Waltenberger, A., and Katinger, H.(1996). “An in-vitro test system for thyroid-hormone action.” Anal. Biochem., 234(1), 56–59.
Holm, J. V., Rügge, K., Bjerg, P. J., and Christensen, T. H.(1995). “Occurrence and distribution of pharmaceutical organic compounds in the groundwater downgradient of a landfill (Grindsted, Denmark).” Environ. Sci. Technol., 29(5), 1415–1420.
Huang, C.-H., and Sedlak, D. L.(2001). “Analysis of estrogenic hormones in municipal wastewater effluent and surface water using enzyme-linked immunosorbent assay and gas chromatography/tandem mass spectrometry.” Environ. Toxicol. Chem., 20(1), 133–139.
Inoue, K., Okumura, H., Higuchi, T., Oka, H., Yoshimura, Y., and Nakazawa, H.(2002). “Characterization of estrogenic compounds in medical polyvinyl chloride tubing by gas chromatography-mass spectrometry and estrogen receptor binding assay.” Clin. Chim. Acta, 325(1–2), 157–163.
Jeannot, R., Sabik, H., Sauvard, E., and Genin, E.(2000). “Application of liquid chromatography with mass spectrometry combined with photodiode array detection and tandem mass spectrometry for monitoring pesticides in surface waters.” J. Chromatogr. A ,879(1), 51–71.
Jobling, S., Noylan, M., Tyler, C. R., Brighty, G., and Sumpter, J. P.(1998). “Widespread sexual disruption in wild fish.” Environ. Sci. Technol., 32, 2498–2506.
Jobling, S., Sheahan, D., Osborne, J. A., Matthiessen, P., and Sumpter, J. P.(1996). “Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals.” Environ. Toxicol. Chem., 15(2), 194–202.
Jobling, S., and Sumpter, J. P.(1993). “Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes.” Aquat. Toxicol., 27, 361–372.
Johnson, L., Casillas, E., Sol, S., Collier, T., Stein, J., and Varanasi, U.(1993). “Contaminant effects on reproductive success in selected benthic fish.” Mar. Environ. Res., 35, 165–170.
Khim, J. S., Kannan, K., Villeneuve, D. L., Koh, C. H., and Giesy, J. P.(1999a). “Characterization and distribution of trace organic contaminants in sediment from Masan Bay, Korea. I: Instrumental analyses.” Environ. Sci. Technol., 33(23), 4199–4205.
Khim, J. S., Villeneuve, D. L., Kannan, K., and Giesy, J. P.(1999b). “Characterization and distribution of trace organic contaminants in sediment from Masan Bay, Korea. II: In vitro gene expression assays.” Environ. Sci. Technol., 33(23), 4206–4211.
Khim, J. S., Villeneuve, D. L., Kannan, K., Lee, K. T., Snyder, S. A., Koh, C. H., and Giesy, J. P.(1999c). “Alkylphenols, polycyclic aromatic hydrocarbons, and organochlorines in sediment from Lake Shihwa, Korea: Instrumental and bioanalytical characterization.” Environ. Toxicol. Chem., 18(11), 2424–2432.
Kindler, P. M., Bahr, J. M., and Philipp, D. P.(1991). “The effects of exogenous 11-ketotestosterone, testosterone, and cyproterone acetate on prespawning and parental care behaviors of male bluegill.” Horm. Behav., 25, 410–423.
Kiso, Y., Nishimura, Y., Kitao, T., and Nishimura, K.(2000). “Rejection properties of non-phenylic pesticides with nanofiltration membranes.” J. Membr. Sci., 171(2), 229–237.
Kiso, Y., Sugiura, Y., Kitao, T., and Nishimura, K.(2001). “Effects of hydrophobicity and molecular size on rejection of aromatic pesticides with nanofiltration membranes.” J. Membr. Sci., 192(1–2), 1–10.
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., and Buxton, H. T.(2002). “Pharmaceuticals, hormones, and other organic waste contaminants in U.S. streams, 1999–2000: A national reconnaissance.” Environ. Sci. Technol., 36(6), 1202–1211.
Kubeck, E., and Naylor, C. G.(1990). “Trace analysis of alkylphenol ethoxylates.” J. Am. Oil Chem. Soc., 67(6), 400–405.
Kuch, H. M., and Ballschmiter, K.(2001). “Determination of endocrine-disrupting phenolic compounds and estrogens in surface and drinking water by HRGC-(NCI)-MS in the picogram per liter range.” Environ. Sci. Technol., 35(15), 3201–3206.
Layton, A. C., Gregory, B. W., Seward, J. R., Schultz, T. W., and Sayler, G. S.(2000). “Mineralization of steroidal hormones by biosolids in wastewater treatment systems in Tennessee USA.” Environ. Sci. Technol., 34(18), 3925–3931.
Leppard, G. G., Flannigan, D. T., Mavrocordatos, D., Marvin, C. H., Bryant, D. W., and McCarry, B. E.(1998). “Binding of polycyclic aromatic hydrocarbons by size classes of particulate in Hamilton Harbor water.” Environ. Sci. Technol., 32(22), 3633–3639.
Lindstrom, A., Buerge, I. J., Poiger, T., Bergqvist, P. A., Muller, M. D., and Buser, H. R.(2002). “Occurrence and environmental behavior of the bactericide triclosan and its methyl derivative in surface waters and in wastewater.” Environ. Sci. Technol., 36(11), 2322–2329.
MacLatchy, D., Peters, L., Nickle, J., and Van Der Kraak, G.(1997). “Exposure to β-sitosterol alters the endocrine status of goldfish differently than 17á-estradiol.” Environ. Toxicol. Chem., 16(9), 1895–1904.
MacLatchy, D. L., and Van Der Kraak, G. J.(1995). “The phytoestrogen β-sitosterol alters the reproductive endocrine status of goldfish.” Toxicol. Appl. Pharmacol., 134, 305–312.
Magnuson, M. L.(1998). “Determination of bromate at parts-per-trillion levels by gas chromatography-mass spectrometry with negative chemical ionization.” Anal. Chim. Acta, 377(1), 53–60.
Mandrioli, R., Albani, F., Casamenti, G., Sabbioni, C., and Raggi, M. A.(2001). “Simultaneous high-performance liquid chromatography determination of carbamazepine and five of its metabolites in plasma of epileptic patients.” J. Chromatogr., B: Biomed. Appl., 762(2), 109–116.
Manning, B. A., Fendorf, S. E., Bostick, B., and Suarez, D. L.(2002). “Arsenic(III) oxidation and arsenic(V) adsorption reactions on synthetic birnessite.” Environ. Sci. Technol., 36(5), 976–981.
Mascher, H., and Kikuta, C.(1990). “Determination of amoxicillin in plasma by high-performance liquid-chromatography with fluorescence detection after online oxidation.” J. Chromatogr., 506, 417–421.
McKinlay, R. G., and Kasperek, K.(1999). “Observations on decontamination of herbicide-polluted water by marsh plant systems.” Water Res., 33(2), 505–511.
McMaster, M. E., Van Der Kraak, G. J., Portt, C. B., Munkittrick, K. R., Sibley, P. K., Smith, I. R., and Dixon, D. G.(1991). “Changes in hepatic mixed-function oxygenase (MFO) activity, plasma steroid levels and age at maturity of a white sucker (Catostomus commersoni) population exposed to bleached kraft pulp mill effluent.” Aquat. Toxicol., 21, 199–218.
Mekenyan, O., Kamenska, V., Serafimova, R., Poellinger, L., Brouwer, A., and Walker, J.(2002). “Development and validation of an average mammalian estrogen receptor-based QSAR model.” SAR QSAR Environ. Res., 13(6), 579–595.
Miles-Richardson, S. R., Pierens, S. L., Nichols, K. M., Kramer, V. J., Snyder, E. M., Snyder, S. A., Render, J. A., Fitzgerald, S. D., and Giesy, J. P.(1999). “Effects of waterborne exposure to 4-nonylphenol and nonylphenol ethoxylate on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas).” Environ. Res., 80, S122–S137.
Monosson, E., Fleming, W. J., and Sullivan, C. V.(1994). “Effects of the planar PCB 3,3′4,4′-tetrachlorobiphenyl (TCB) on ovarian development, plasma levels of sex steroid hormones and vitellogenin, and progeny survival in the white perch ({Morone americana}).” Aquat. Toxicol., 29, 1–19.
Mouvet, C., and Jucker, C.(1997). “Influence of various filters on the concentration of pesticides dissolved in water.” Environ. Sci. Technol., 31(8), 2434–2437.
Nasu, M., Goto, M., Kato, H., Oshima, Y., and Tanaka, H.(2001). “Study on endocrine disrupting chemicals in wastewater treatment plants.” Water Sci. Technol., 43(2), 101–108.
Ohno, K.-I., Fukushima, T., Santa, T., Waizumi, N., Tokuyama, H., Maeda, M., and Imai, K.(2002). “Estrogen receptor binding assay method for endocrine disruptors using fluorescence polarization.” Anal. Chem., 74(17), 4391–4396.
Pereira, J. J., Mercaldo-Allen, R., Kuropat, C., Luedke, D., and Sennefelder, G.(1993). “Effect of cadmium accumulation on serum vitellogenin levels and hepatosomatic and gonadosomatic indices of winter flounder ({Pleuronectes americanus}).” Arch. Environ. Contam. Toxicol., 24, 427–431.
Petty, J. D., Jones, S. B., Huckins, J. N., Cranor, W. L., Parris, J. T., McTague, T. B., and Boyle, T. P.(2000). “An approach for assessment of water quality using semipermeable membrane devices (SPMDs) and bioindicator tests.” Chemosphere, 41(2000), 311–321.
Pons, M., Gagne, D., Nicolas, J. C., and Mehtali, M.(1990). “A new cellular model of response to estrogens: A bioluminescent test to characterize (anti)estrogen molecules.” BioTechniques, 9, 450–459.
Pryor, S. W., Hay, A. G., and Walker, L. P.(2002). “Nonylphenol in anaerobically digested sewage sludge from New York state.” Environ. Sci. Technol., 36(17), 3678–3682.
Putschew, A., Wischnack, S., and Jekel, M.(2000). “Occurrence of triiodinated X-ray contrast agents in the aquatic environment.” Sci. Total Environ., 255(1–3), 129–134.
Rahman, F., Langford, K. H., Scrimshaw, M. D., and Lester, J. N.(2001). “Polybrominated diphenyl ether (PBDE) flame retardants.” Sci. Total Environ., 275(1–3), 1–17.
Ravelet, C., Grosset, C., Montuelle, B., Benoit-Guyod, J. L., and Alary, J.(2001). “Liquid chromatography study of pyrene degradation by two micromycetes in a freshwater sediment.” Chemosphere, 44(7), 1541–1546.
Rimkus, G. G.(1999). “Polycyclic musk fragrances in the aquatic environment.” Toxicol. Lett., 111(1–2), 37–56.
Romero, J., Ventura, F., and Gomez, M.(2002). “Characterization of paint samples used in drinking water reservoirs: Identification of endocrine disruptor compounds.” J. Chromatogr. Sci., 40(4), 191–197.
Routledge, E. J., Sheahan, D., Desbrow, C., Brighty, G. C., Waldock, M., and Sumpter, J. P.(1998). “Identification of estrogenic chemicals in STW effluent. II: In vivo responses in trout and roach.” Envir. Toxicol. Chem., 32(11), 1559–1565.
Ruiz Encinar, J., Rodriquez-Gonzalez, P., Rodriguez Fernandez, J., Garzia Alonso, J. I., Diez, S., Bayona, J. M., and Sanz-Medel, A.(2002). “Evaluation of accelerated solvent extration for butyltin speciations in PACS-2 CRM using double-spike isotope dilution-GC/ICPMS.” Anal. Chem., 74(20), 5237–5242.
Salov, V. V., Yoshinaga, J., Shibata, Y., and Morita, M.(1992). “Determination of inorganic halogen species by liquid chromatography with inductively coupled argon plasma mass spectrometry.” Anal. Chem., 64(20), 2425–2428.
Sanderson, J. T., Aarts, J. M., Brouwer, A., Froese, K. L., Denison, M. S., and Giesy, J. P.(1996). “Comparison of Ah receptor-mediated luciferase and ethoxyresorufin O-deethylase induction in H4IIE cells: Implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons.” Toxicol. Appl. Pharmacol., 137, 316–325.
Schults, D. W., Ferraro, S. P., Smith, L. M., Roberts, F. A., and Poindexter, C. K.(1992). “A comparison of methods for collecting interstitial water for trace organic-compounds and metals analyses.” Water Res., 26(7), 989–995.
Segner, H., Navas, J. M., Schäfers, C., and Wenzel, A.(2003). “Potencies of estrogenic compounds in in vitro screening assays and in life cycle tests with zebrafish in vivo.” Ecotoxicol. Environ. Saf., 54(3), 315–322.
Seiler, R. L., Zaugg, S. D., Thomas, J. M., and Howcroft, D. L.(1999). “Caffeine and pharmaceuticals as indicators of waste water contamination in wells.” Ground Water, 37(3), 405–410.
Singh, P. B., Kime, D. E., Epler, P., and Chyb, J.(1994). “Impact of γ-hexachlorocyclohexane exposure on plasma gonadotropin levels and in vitro stimulation of gonadal steroid production by carp hypophyseal homogenate in Carassius auratus.” J. Fish Biol., 44, 195–204.
Snyder, S. A., Keith, T. L., Naylor, C. G., Staples, C. A., and Giesy, J. P.(2001a). “Identification and quantification method for nonylphenol and lower oligomer nonylphenol ethoxylates in fish tissues.” Environ. Toxicol. Chem., 20(9), 1870–1873.
Snyder, S. A., Keith, T. L., Verbrugge, D. A., Snyder, E. M., Gross, T. S., Kannan, K., and Giesy, J. P.(1999). “Analytical methods for detection of selected estrogenic compounds in aqueous mixtures.” Environ. Sci. Technol., 33(16), 2814–2820.
Snyder, S. A., Kelly, K. L., Grange, A. H., Sovocool, G. W., Snyder, E. M., and Giesy, J. P. (2001b). “Pharmaceuticals and personal care products in the waters of Lake Mead, Nevada.” Pharmaceuticals and personal care products in the environment: Scientific and regulatory issues, C. G. Daughton and T. L. Jones-Lepp, eds., American Chemical Society, Washington, D.C., 116–140.
Snyder, E. M., Snyder, S. A., Giesy, J. P., Blonde, S. A., Hurlburt, G. K., Summer, C. L., Mitchell, R. R., and Bush, D. M.(2000a). “SCRAM: A scoring and ranking model for persistent bioaccumulative and toxic substances for the north American great lakes. I: Structure of the scoring and ranking system.” Environ. Sci. Pollut. Res., 7(1), 52–61.
Snyder, S. A., Snyder, E., Villeneuve, D., Kurunthachalam, K., Villalobos, A., Blankenship, A., and Giesy, J. (2000b). “Instrumental and bioanalytical measures of endocrine disruptors in water.” Analysis of environmental endocrine disruptors, L. H. Keith, T. L. Jones-Lepp, and L. L. Needham, eds., American Chemical Society, Washington, D.C., 73–95.
Snyder, S. A., Villeneuve, D. L., Snyder, E. M., and Giesy, J. P.(2001c). “Identification and quantification of estrogen receptor agonists in wastewater effluents.” Environ. Sci. Technol., 35(18), 3620–3625.
Sole, M., Castillo, M., Lopez de Alda, M. J., Porte, C., Ladegaard-Pedersen, K., and Barcelo, D.(2000). “Estrogenicity determination in sewage treatment plants and surface waters from the Catalonian area (NE Spain).” Environ. Sci. Technol., 34(24), 5076–5083.
Soto, A. M., Lin, T. M., Justicia, H., Silvia, R. M., and Sonnenschein, C. (1992). “An “in culture” bioassay to assess the estrogencity of xenobiotics (e-screen).” Chemically-induced alterations in sexual and functional development: The wildlife/human connection, T. Colburn and C. Clement, eds., Princeton Scientific, Princeton, N.J., 295–310.
Steger-Hartmann, T., Lange, R., Schweinfurth, H., Tschampel, M., and Rehmann, I.(2002). “Investigations into the environmental fate and effects of iopromide (ultravist), a widely used iodinated X-ray contrast medium.” Water Res., 36(1), 266–274.
Stumpf, M., Ternes, T. A., Rolf-Dieter, W., Rodrigues, S. V., and Baumann, W.(1999). “Polar drug residues in sewage and natural waters in the state of Rio de Janeiro, Brazil.” Sci. Total Environ., 225, 135–141.
Ternes, T. A.(1998). “Occurrence of drugs in German sewage treatment plants and rivers.” Water Res., 32(11), 3245–3260.
Ternes, T. A.(2001). “Analytical methods for the determination of pharmaceuticals in aqueous environmental samples.” Trends Analyt. Chem., 20(8), 419–434.
Ternes, T., Bonerz, M., and Schmidt, T.(2001). “Determination of neutral pharmaceuticals in wastewater and rivers by liquid chromatography-electrospray tandem mass spectrometry.” J. Chromatogr., A, 938(1–2), 175–185.
Ternes, T. A., and Hirsch, R.(2000). “Occurrence and behavior of x-ray contrast media in sewage facilities and the aquatic environment.” Environ. Sci. Technol., 34, 2741–2748.
Tsuda, T., Takino, A., Muraki, K., Harada, H., and Kojima, M.(2001). “Evaluation of 4-nonylphenols and 4-tert-octylphenol contamination of fish in rivers by laboratory accumulation and excretion experiments.” Water Res., 35(7), 1786–1792.
U.S. Environmental Protection Agency. (1997). “Special report on environmental endocrine disruption: An effects assessment and analysis.” Office of Research and Development, Washington, D.C. February 1997, EPA/630/R-96/012, U.S. Environmental Protection Agency, Cincinnati.
U.S. Environmental Protection Agency. (1998). “Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) final report.” U.S. Environmental Protection Agency, Cincinnati.
van Aerle, R., Pounds, N., Hutchinson, T. H., Maddix, S., and Tyler, C. R.(2002). “Window of sensitivity for the estrogenic effects of ethinylestradiol in early life-stages of fathead minnow, Pimephales promelas.” Ecotoxicology, 11(6), 423–434.
Van der Bruggen, B., Everaert, K., Wilms, D., and Vandecasteele, C.(2001). “Application of nanofiltration for removal of pesticides, nitrate and hardness from ground water: Rejection properties and economic evaluation.” J. Membr. Sci., 193(2), 239–248.
Van Der Kraak, G. J., Munkittrick, K. R., McMaster, M. E., Portt, C. B., and Chang, J. P.(1992). “Exposure to bleached kraft pulp mill effluent disrupts the pituitary-gonadal axis of white sucker at multiple sites.” Toxicol. Appl. Pharmacol., 115, 224–233.
Voordeckers, J. W., Fennell, D. E., Jones, K., and Haggblom, M. M.(2002). “Anaerobic biotransformation of tetrabromobisphenol A, tetrachlorobisphenol A, and bisphenol A in estuarine sediments.” Environ. Sci. Technol., 36(4), 696–701.
Weigel, S., Bester, K., and Huhnerfuss, H.(2001). “New method for rapid solid-phase extraction of large-volume water samples and its application to non-target screening of North Sea water for organic contaminants by gas chromatography-mass spectrometry.” J. Chromatogr., A, 912(1), 151–161.
Witters, H. E., Vangenechten, C., and Berckmans, P.(2001). “Detection of estrogenic activity in Flemish surface waters using an in vitro recombinant assay with yeast cells.” Water Sci. Technol., 43(2), 117–123.
Yamagishi, T., Miyazaki, T., Horii, S., and Akiyama, K.(1983). “Synthetic musk residues in biota and water from Tama River and Tokyo Bay (Japan).” Arch. Environ. Contam. Toxicol., 12(1), 83–89.
Yook, K.-S., Hong, S.-M., and Kim, J.-H.(1994). “Comparison of liquid-liquid extraction and solid-phase extraction coupled with GC/MS for determination of priority pollutants in water.” Anal. Sci. Technol., 7(4), 441–453.
Zacharewski, T.(1997). “In vitro bioassays for assessing estrogenic substances.” Environ. Sci. Technol., 31(3), 613–623.
Information & Authors
Information
Published In
Practice Periodical of Hazardous, Toxic, and Radioactive Waste Management
Volume 7 • Issue 4 • October 2003
Pages: 224 - 234
Copyright
Copyright © 2003 American Society of Civil Engineers.
History
Received: Mar 24, 2003
Accepted: Jun 9, 2003
Published online: Sep 15, 2003
Published in print: Oct 2003
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