Research Article
Feb 1978
Properties of Intimal Layer and Adjacent Flow
Authors: Ramesh N. Vaishnav, Dali J. Patel, and H. Bulent AtabekAuthor Affiliations
Publication: Journal of the Engineering Mechanics Division
Volume 104, Issue 1
Abstract
The importance of the information on mechanical properties of the intimal layer and adjacent flow fields in studies of vessel wall permeability and pathogenesis of atherosclerosis is well recognized. The intimal layer was studied in excised segments of the blood vessel stretched to in vivo dimensions. The endothelium could withstand large normal stresses but was easily eroded by the shear stress resulting from a jet efflux. Relatively hard areas in the intimal layer distal to the intercostal orifices were found to relate to the increased collagen content and lower permeability to Evans blue dye. With the nonlinear theory of blood flow it was possible to compute accurately the pulsatile velocity profile and wall shear during a cardiac cycle in the descending thoracic aorta of a dog. The peak wall shear, under conditions of increased flow, approached the value 270 dyne/cm²; this value is close to the critical yield stress (400 dyne/cm²) for endothelial cells.
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Information
Published In
Journal of the Engineering Mechanics Division
Volume 104 • Issue 1 • February 1978
Pages: 67 - 77
Copyright
© 1978 American Society of Civil Engineers.
History
Published in print: Feb 1978
Published online: Feb 3, 2021
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Authors
Affiliations
Ramesh N. Vaishnav
Prof. of Civ. Engrg., The Catholic Univ. of America, Washington, D.C.
Dali J. Patel
Medical Officer, The Section on Vascular Physiology, Lab. of Experimental Atherosclerosis, National Heart, Lung, and Blood Inst., The National Insts. of Health, Bethesda, Md.
H. Bulent Atabek
Prof. of Mech. Engrg., The Catholic Univ. of America, Washington, D.C.
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