Laboratory Investigation of Antibiotic Interactions with Nanoparticles in Water
Publication: Journal of Environmental Engineering
Volume 142, Issue 5
Abstract
The movement and degradation of drugs in soil and water environments are related to surface interactions with oxide nanoparticles. These nanoparticles could be stationary substrates or suspended in aqueous solution. In this study, different pH solutions of the common antibiotic ampicillin (AMP) were mixed with (maghemite) particles. Both sorption and breakdown of AMP were observed. For initial drug concentrations from to 2.9 mM, the overall AMP removal from solution can be described by linear isotherms with removal coefficients () of 394 () at pH 2, 551 () at pH 6, and 256 () at pH 8. At pH 4, AMP removal can be described by a Freundlich isotherm of () and (). AMP solutions were separated from maghemite nanoparticles after mixing and analyzed by liquid chromatography/mass spectroscopy (LC/MS) techniques, resulting in the detection of penicilloic and penilloic acid breakdown products.
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Acknowledgments
Partial funding for the research was provided by the NASA-Michigan Space Grant Consortium Seed Grant Program, Howard Hughes Medical Institute, and the Hope College Department of Geological & Environmental Sciences, and the Hope College Chemistry Department. A special thank you is extended to team members Nicholas Powers, Amanda Schuiling, and Drew Shaw for their assistance.
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Published In
Journal of Environmental Engineering
Volume 142 • Issue 5 • May 2016
Copyright
© 2016 American Society of Civil Engineers.
History
Received: Jan 27, 2015
Accepted: Nov 3, 2015
Published online: Jan 22, 2016
Published in print: May 1, 2016
Discussion open until: Jun 22, 2016
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