Treatment of High-Strength Pharmaceutical Wastewater and Removal of Antibiotics in Anaerobic and Aerobic Biological Treatment Processes
Publication: Journal of Environmental Engineering
Volume 132, Issue 1
Abstract
Anaerobic and aerobic treatment of high-strength pharmaceutical wastewater was evaluated in this study. A batch test was performed to study the biodegradability of the wastewater, and the result indicated that a combination anaerobic-aerobic treatment system was effective in removing organic matter from the high-strength pharmaceutical wastewater. Based on the batch test, a pilot-scale system composed of an anaerobic baffled reactor followed by a biofilm airlift suspension reactor was designed. At a stable operational period, effluent chemical oxygen demand (COD) from the anaerobic baffled reactor ranged from 1,432 to at a hydraulic retention time (HRT) of 1.25 day, and 979 to at an HRT of 2.5 day, respectively, when influent COD ranged from 9,736 to . As a result, effluent COD of the biofilm airlift suspension reactor varied between 256 and at HRTs of from 5.0 to 12.5 h. The antibiotics ampicillin and aureomycin, with influent concentrations of 3.2 and , respectively, could be partially degraded in the anaerobic baffled reactor: ampicillin and aureomycin removal efficiencies were 16.4 and 25.9% with an HRT of 1.25 day, and 42.1 and 31.3% with HRT of 2.5 day, respectively. Although effective in COD removal, the biofilm airlift suspension reactor did not display significant antibiotic removal, and the removal efficiencies of the two antibiotics were less than 10%.
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Acknowledgments
The laboratory assistance of Ms. Xiuyu Zhang and Ms. Xiaojuan Ruan, Water Quality Laboratory, Fuzhou Pharmaceutical Company, is greatly appreciated.
References
Adams, C., Wang, Y., Loftin, K., and Meyer, M. (2002). “Removal of antibiotics from surface and distilled water in conventional water treatment processes.” J. Environ. Eng., 128, 253–260.
Al-Ahmad, A., Daschner, F. D., and Kummerer, K. (1999). “Biodegradability of cefotiam, ciprofloxacin, meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria.” Arch. Environ. Contam. Toxicol., 37, 158–163.
Arslan-Alaton, I., and Balcioglu, I. A. (2002). “Biodegradability assessment of ozonated raw and biotreated pharmaceutical wastewater.” Arch. Environ. Contam. Toxicol., 43, 425–431.
Balcioglu, I. A., and Otker, M. (2002). “Treatment of pharmaceutical wastewater containing antibiotics by and processes.” Chemosphere, 50, 85–95.
Barber, W. P., and Stuckey, D. C. (1999). “The use of the anaerobic baffled reactor (ABR) for wastewater treatment: A review.” Water Res., 33, 1559–1578.
Beccari, M., Majone, M., Papini, M. P., and Torrisi, L. (2001). “Enhancement of anaerobic treatability of olive oil mill effluents by addition of and bentonite without intermediate solid/liquid separation.” Water Sci. Technol., 43, 275–282.
Buitron, G., Melgoza, R. M., and Jimenez, L. (2003). “Pharmaceutical wastewater treatment using an anaerobic/aerobic sequencing batch biofilter.” J. Environ. Sci. Health, Part A: Toxic/Hazard. Subst. Environ. Eng., 38, 2077–2088.
Cinquina, A. L., Longo, F., Anastasi, G., Giannetti, L., and Cozzani, R. (2003). “Validation of a high-performance liquid chromatography method for the determination of oxytetracycline, tetracycline, chlortetracycline and doxycycline in bovine milk and muscle.” J. Chromatogr., A, 987, 227–233.
Fox, P., and Venkatasubbiah, V. (1996). “Coupled anaerobic/aerobic treatment of high-sulfate wastewater with sulfate reduction and biological sulfide oxidation.” Water Sci. Technol., 34, 359–366.
Frere, J. (1995). “Beta-lactamases and bacterial resistance to antibiotics.” Mol. Microbiol., 16, 385–395.
Halling-Sorensen, B., Lykkeberg, A., Ingerslev, F., Blackwell, P., and Tjornelund, J. (2003). “Characterisation of the abiotic degradation pathways of oxytetracyclines in soil interstitial water using LC-MS-MS.” Chemosphere, 50, 1331–1342.
Harding, R. C., Hill, G. A., and Lin, Y. H. (2003). “Bioremediation of toluene-contaminated air using an external loop airlift bioreactor.” J. Chem. Technol. Biotechnol., 78, 406–411.
Heijnen, J. J., van Loosdrecht, M. C. M., Mulder, R., Weltevrede, R., and Mulder, A. (1991). “Large scale anaerobic-aerobic treatment of complex industrial wastewater using biofilm reactor.” Water Sci. Technol. 23, 1427–1436.
Ince, B. K., Selcuk, A., and Ince, O. (2002). “Effect of a chemical synthesis-based pharmaceutical wastewater on performance: Acetoclastic methanogenic activity and microbial population in an upflow anaerobic filter.” J. Chem. Technol. Biotechnol., 77, 711–719.
Langenhoff, A. A. M., Intrachandar, N., and Stuckey, D. C. (2000). “Treatment of dilute soluble and colloidal wastewater using an anaerobic baffled reactor: iNfluence of hydraulic retention time.” Water Res., 34, 1307–1317.
Lansky, P., and Halling-Sorensen, B. (1997). “The toxic effect of the antibiotic mentronidazol on aquatic organisms.” Chemosphere, 35, 2553–2561.
Li, Y. M., Gu, G. W., Zhao, I., Yu, H. Q., Qiu, Y. L., and Peng, Y. Z. (2003). “Treatment of coke-plant wastewater by biofilm systems for removal of organic compounds and nitrogen.” Chemosphere, 52, 997–1005.
Loke, M., Jespersen, S., Vreeken, R., Halling-Sorensen, B., and Tjornelund, J. (2003). “Determination of oxytetracycline and its degradation products by high-performance liquid chromatography-tandem mass spectrometery in manure-containing anaerobic test system.” J. Chromatogr., B: Biomed. Appl., 783, 11–23.
Metcalf & Eddy. (1991). Wastewater engineering: Treatment, disposal, and reuse, McGraw-Hill, New York, 373.
Minke, R., and Rott, U. (1999). “Anaerobic treatment of split flow wastewater and concentrates from the textile processing industry.” Water Sci. Technol., 40, 169–176.
Mosquera-Corral, A., Montras, A., Heijnen, J. J., and van Loosdrech, M. C. M. (2003). “Degradation of polymers in a biofilm airlift suspension reactor.” Water Res., 37, 485–492.
Nandy, T., and Kaul, N. (2001). “Anaerobic pre-treatment of herbal-based pharmaceutical wastewater using fixed-film reactor with recourse to energy recovery.” Water Res., 35, 351–362.
Oz, N. A., Ince, O., Ince, B. K., Akarsubasi, A. T., and Eyice, O. (2003). “Microbial population dynamics in an anaerobic CSTR treating a chemical synthesis-based pharmaceutical wastewater.” J. Environ. Sci. Health, 38, 2029–2042.
Pajchel, G., Pawlowski, K., and Tyski, S. (2002). “CE versus LC for simultaneous determination of amoxicillin/clavulanic acid and ampicillin/sulbactam in pharmaceutical formulations for injection.” J. Pharm. Biomed. Anal, 29, 75–81.
Rosen, M., Welander, T., Lofqvist, A., and Holmgren, J. (1998). “Development of a new process for treatment of a pharmaceutical wastewater.” Water Sci. Technol., 37, 251–258.
Stamatelatou, K., Vavilin, V., and Lyberatos, G. (2003). “Performance of a glucose fed periodic anaerobic baffled reactor under increasing organic loading conditions. 1: Experimental results.” Bioresour. Technol., 88, 131–136.
Sunderland, J., Lovering, A. M., Tobin, C. M., MacGowan, A. P., Roe, J. M., and Delsol, A. A. (2003). “Determination by HPLC of chlortetracycline in pig faeces.” J. Antimicrob. Chemother., 52, 135–137.
Wang, B., and Shen, Y. (2001). “Performance of an anaerobic baffled reactor (ABR) as a hydrolysis-acidogenesis unit in treating landfill leachate mixed with municipal sewage.” Water Sci. Technol. 42, 115–121.
Wang, X., Mize, T. H., Saunders, F. M., and Baker, S. A. (1997). “Biotreatability test of bleach wastewaters from pulp and paper mills.” Water Sci. Technol. 35, 101–108.
Zhou, P., He, J., and Qian, Y. (2003). “Biofilm airlift suspension reactor treatment of domestic wastewater.” Water, Air, Soil Pollut., 144, 81–100.
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Received: Feb 3, 2004
Accepted: May 10, 2005
Published online: Jan 1, 2006
Published in print: Jan 2006
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