Inactivation Kinetics of Viral Aggregates
Publication: Journal of Environmental Engineering
Volume 121, Issue 4
Abstract
A kinetic model is developed for the inactivation of viruses that exhibit a range of initial aggregate sizes. Aggregates are assumed to be more resistant to inactivation than single virions because (1) all virions within an aggregate must be inactivated before the aggregate as a whole is considered inactive; and (2) undamaged components of inactive virions within an aggregate may recombine to cause host-cell infection (multiplicity reactivation). Survival curves calculated from the model compare well with inactivation data published in a previous study. The analysis presented in this report provides an approach for estimating the contact time (or disinfection concentration) required to inactivate viral aggregates, and a framework for predicting virus survival in water-treatment systems and natural environments.
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Information & Authors
Information
Published In
Journal of Environmental Engineering
Volume 121 • Issue 4 • April 1995
Pages: 311 - 319
Copyright
Copyright © 1995 American Society of Civil Engineers.
History
Published online: Apr 1, 1995
Published in print: Apr 1995
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