Technical Papers
Oct 19, 2020

Epistemic Uncertainty in Site Response as Derived from One-Dimensional Ground Response Analyses

This article has a reply.
VIEW THE REPLY
This article has a reply.
VIEW THE REPLY
Publication: Journal of Geotechnical and Geoenvironmental Engineering
Volume 147, Issue 1

Abstract

One-dimensional ground response analyses (GRAs) are often used with an expectation that they provide unbiased estimates of site effects. Under that hypothesis, epistemic uncertainty in site response arises mainly from uncertain soil properties. This approach has dominated practice for projects where site-specific site response is estimated for use in probabilistic seismic hazard analyses. We extend the uncertainty framework to also consider modeling errors (i.e., inability of GRAs to model site response for some sites). We quantify this epistemic uncertainty using vertical array data in which the downhole motion is input to GRAs to predict ground motions at the surface. Residuals (i.e., difference between observed and predicted ground motion intensity measures in natural log units) are partitioned into between- and within-site components. After correcting for overprediction bias near the site period, we quantify epistemic uncertainty using between-site standard deviation, which ranges from 0.2 to 0.35 using California data. A Japan data set analyzed in the literature provides similar results. This dispersion is only modestly smaller than the site-to-site variability from ergodic models for active tectonic regions, which limits the apparent benefits of site-specific GRAs. Dispersion results are not appreciably affected by varying damping models, although a model informed by site-specific observations minimizes bias relative to alternative models based on geotechnical laboratory tests and seismological crustal attenuation studies.

Get full access to this article

View all available purchase options and get full access to this article.

Data Availability Statement

The data used in this study is publically available (Afshari et al. 2018). Details on the data set and how to access it are provided in Afshari et al. (2019).

Acknowledgments

Funding for this study was provided by the California Strong Motion Instrumentation Program, California Geological Survey, Agreement No. 1014-961. Partial support was also provided by the UCLA Civil and Environmental Engineering Department. This support is gratefully acknowledged. We are appreciative of Tadahiro Kishida of the Khalifa University of Science Technology and Research and Yousef Bozorgnia of UCLA for providing access to data processing codes and their efforts in developing data resources used in this study. We also thank Hamid Haddadi of CSMIP for providing weak motion records from the Center for Engineering Strong Motion Data FTP folders, and Javier Vargas Ortiz, Bahareh Heidarzadeh, and Jamison Steidl for providing geotechnical logs for vertical array sites considered in this project. We appreciate constructive feedback on this general line of research from Julian Bommer, Eric Thompson, James Kaklamanos, and Adrian Rodriguez-Marek. We appreciate the reviews of this paper by James Kaklamanos, Fabian Bonilla, one anonymous reviewer, and the associate editor.

References

Afacan, K. B., S. Yneista, A. Shafiee, J. P. Stewart, and S. J. Brandenberg. 2019. “Total stress analysis of soft clay ground response in centrifuge models.” J. Geotech. Geoenviron. Eng. 145 (10): 04019061. https://doi.org/10.1061/(ASCE)GT.1943-5606.0002115.
Afshari, K., and J. P. Stewart. 2017. Implications of California vertical array data for the analysis of site response with 1D geotechnical modeling. Los Angeles: Univ. of California.
Afshari, K., and J. P. Stewart. 2019. “Insights from California vertical arrays on the effectiveness of ground response analysis with alternative damping models.” Bull. Seismol. Soc. Am. 109 (4): 1250–1264. https://doi.org/10.1785/0120180292.
Afshari, K., J. P. Stewart, and J. H. Steidl. 2018. Ground motion data from California vertical arrays. Austin, TX: DesignSafe-CI.
Afshari, K., J. P. Stewart, and J. H. Steidl. 2019. “California ground motion vertical array database.” Earthquake Spectra 35 (4): 2003–2015. https://doi.org/10.1193/070218EQS170DP.
Al Atik, L. 2015. NGA-East: Ground motion standard deviation models for Central and Eastern North America. Berkeley, CA: Univ. of California.
Al Atik, L., N. Abrahamson, J. J. Bommer, F. Scherbaum, F. Cotton, and N. Kuehn. 2010. “The variability of ground motion prediction models and its components.” Seismol. Res. Lett. 81 (5): 794–801. https://doi.org/10.1785/gssrl.81.5.794.
Ancheta, T. D., et al. 2014. “NGA-West2 database.” Earthquake Spectra 30 (3): 989–1005. https://doi.org/10.1193/070913EQS197M.
Atkinson, G. M. 2006. “Single-station sigma.” Bull. Seism. Soc. Am. 96: 446–455. https://doi.org/10.1785/0120050137.
Bazzurro, P., and C. A. Cornell. 2004a. “Nonlinear soil-site effects in probabilistic seismic-hazard analysis.” Bull. Seismol. Soc. Am. 94 (6): 2110–2123. https://doi.org/10.1785/0120030216.
Bazzurro, P., and C. A. Cornell. 2004b. “Ground motion amplification in nonlinear soil sites with uncertain properties.” Bull. Seismol. Soc. Am. 94 (6): 2090–2109. https://doi.org/10.1785/0120030215.
Bommer, J. J. 2012. “Challenges of building logic trees for probabilistic seismic hazard analysis.” Earthquake Spectra 28 (4): 1723–1735. https://doi.org/10.1193/1.4000079.
Bommer, J. J., et al. 2015. “A SSHAC level 3 probabilistic seismic hazard analysis for a new-build nuclear site in South Africa.” Earthquake Spectra 31 (2): 661–698. https://doi.org/10.1193/060913EQS145M.
Bommer, J. J., and N. A. Abrahamson. 2006. “Why do modern probabilistic seismic hazard analyses lead to increased hazard estimates?” Bull. Seismol. Soc. Am. 96 (6): 1967–1977. https://doi.org/10.1785/0120060043.
Bommer, J. J., and F. Scherbaum. 2008. “The use and misuse of logic trees in probabilistic seismic hazard analysis.” Earthquake Spectra 24 (4): 997–1009. https://doi.org/10.1193/1.2977755.
Bommer, J. J., P. J. Stafford, B. Edwards, B. Dost, E. van Denem, A. Rodriguez-Marek, P. Kruiver, J. van Elk, D. Doornhof, and M. Ntinalexis. 2017. “Framework for a ground motion for induced seismic hazard and risk analysis in the Groningen gas field, the Netherlands.” Earthquake Spectra 33 (2): 481–498. https://doi.org/10.1193/082916EQS138M.
Boore, D. M. 2010. “Orientation-independent, nongeometric-mean measures of seismic intensity from two horizontal components of motion.” Bull. Seismol. Soc. Am. 100 (4): 1830–1835. https://doi.org/10.1785/0120090400.
Boore, D. M., and M. W. Asten. 2008. “Comparisons of shear-wave slowness in the Santa Clara Valley, California, using blind interpretations of data from invasive and noninvasive methods.” Bull. Seismol. Soc. Am. 98 (4): 1983–2003. https://doi.org/10.1785/0120070277.
Boore, D. M., J. P. Stewart, E. Seyhan, and G. M. Atkinson. 2014. “NGA-West 2 equations for predicting PGA, PGV, and 5%-damped PSA for shallow crustal earthquakes.” Earthquake Spectra 30 (3): 1057–1085. https://doi.org/10.1193/070113EQS184M.
Borja, R. I., H. Y. Chao, F. J. Montans, and C. H. Lin. 1999. “Nonlinear ground response at Lotung LSST site.” J. Geotech. Geoenviron. Eng. 125 (3): 187–197. https://doi.org/10.1061/(ASCE)1090-0241(1999)125:3(187).
Cabas, A., A. Rodriguez-Marek, and L. F. Bonilla. 2017. “Estimation of site-specific Kappa (κ0)-consistent damping values at KiK-net sites to assess the discrepancy between laboratory-based damping models and observed attenuation (of seismic waves) in the field.” Bull. Seismol. Soc. Am. 107 (5): 2258–2271. https://doi.org/10.1785/0120160370.
Campbell, K. W. 2009. “Estimates of shear-wave Q and κ0 for unconsolidated and semi consolidated sediments in Eastern North America.” Bull. Seismol. Soc. Am. 99 (4): 2365–2392. https://doi.org/10.1785/0120080116.
Coppersmith, K. L., J. J. Bommer, K. L. Hanson, R. T. Coppersmith, J. Unruh, L. Wolf, R. R. Youngs, L. Al Atik, A. Rodriguez-Marek, and G. Toro. 2014. Hanford site wide probabilistic seismic hazard analysis. Richland, WA: Pacific Northwest National Laboratory.
Darendeli, M. B. 2001. “Development of a new family of normalized modulus reduction and material damping curves.” Ph.D. thesis, Dept. of Civil Engineering, Univ. of Texas.
Elgamal, A., T. Lai, Z. Yang, and L. He. 2001. “Dynamic soil properties, seismic down hole arrays and applications in practice.” In Proc., 4th Int. Conf. Recent Advances in Geotechnical Earthquake Engineering and Soil Dynamics, edited by S. Prakash, 1–85. Rolla, MO: Univ. of Missouri.
EPRI (Electric Power Research Institute). 2013. Seismic evaluation guidance: Screening, prioritization and implementation details (SPID) for the resolution of Fukushima near-term task force recommendation 2.1: Seismic. Palo Alto, CA: EPRI.
GeoPentech. 2015. Southwestern United States ground motion characterization SSHAC level 3. Irvine, CA: GeoPentech.
Goulet, C. A., Y. Bozorgnia, N. Kuehn, L. Al Atik, R. R. Youngs, R. W. Graves, and G. M. Atkinson. 2017. NGA-East ground-motion models for the US Geological Survey national seismic hazard maps. Berkeley, CA: Univ. of California.
Griffiths, S. C., B. R. Cox, E. M. Rathje, and D. P. Teague. 2016. “Surface-wave dispersion approach for evaluating statistical models that account for shear-wave velocity uncertainty.” J. Geotech. Geoenviron. Eng. 142 (11): 04016061. https://doi.org/10.1061/(ASCE)GT.1943-5606.0001552.
Harmon, J., Y. M. A. Hashash, J. P. Stewart, E. M. Rathje, K. W. Campbell, W. J. Silva, B. Xu, M. Musgrove, and O. Ilhan. 2019. “Site amplification functions for central and Eastern North America—Part I: Simulation dataset development.” Earthquake Spectra 35 (2): 787–814. https://doi.org/10.1193/091017EQS178M.
Hashash, Y., J. Harmon, O. Olhan, J. P. Stewart, E. M. Rathje, K. W. Campbell, W. J. Silva, and C. A. Goulet. 2018. “Modelling of site amplification via large scale nonlinear simulations with applications to North America.” In Proc., Geotechnical engineering and soil dynamics V: Seismic hazard analysis, earthquake ground motions, and regional-scale assessment, 523–537. Reston, VA: ASCE.
Hashash, Y. M. A., M. I. Musgrove, J. A. Harmon, D. R. Groholski, C. A. Phillips, and D. Park. 2016. DEEPSOIL 6.1, user manual. Urbana, IL: Univ. of Illinois at Urbana–Champaign.
Hough, S. E., and J. G. Anderson. 1988. “High-frequency spectra observed at Anza, California: Implications for Q structure.” Bull. Seismol. Soc. Am. 78 (2): 692–707.
Kaklamanos, J., L. G. Baise, E. M. Thompson, and L. Dorfmann. 2015. “Comparison of 1D linear, equivalent-linear, and nonlinear site response models at six KiK-net validation sites.” Soil Dyn. Earthquake Eng. 69 (Feb): 435–460. https://doi.org/10.1016/j.soildyn.2014.10.016.
Kaklamanos, J., and B. A. Bradley. 2018. “Challenges in predicting seismic site response with 1D analyses: Conclusions from 114 KiK-net vertical seismometer arrays.” Bull. Seismol. Soc. Am. 108 (5): 2816–2838. https://doi.org/10.1785/0120180062.
Kaklamanos, J., B. A. Bradley, E. M. Thompson, and L. G. Baise. 2013. “Critical parameters affecting bias and variability in site-response analyses using KiK-net down hole array data.” Bull. Seismol. Soc. Am. 103 (3): 1733–1749. https://doi.org/10.1785/0120120166.
Kamai, R., N. A. Abrahamson, and W. J. Silva. 2014. “Nonlinear horizontal site response for the NGA-West 2 project.” Earthquake Spectra 30 (3): 1223–1240. https://doi.org/10.1193/070113EQS187M.
Kim, B., Y. M. A. Hashash, J. P. Stewart, E. M. Rathje, J. A. Harmon, M. I. Musgrove, K. W. Campbell, and W. J. Silva. 2016. “Relative differences between nonlinear and equivalent-linear 1D site response analyses.” Earthquake Spectra 32 (3): 1845–1865. https://doi.org/10.1193/051215EQS068M.
Kramer, S. L. 1996. Geotechnical earthquake engineering. Upper Saddle River, NJ: Prentice Hall.
Kwok, A. O., J. P. Stewart, and Y. M. A. Hashash. 2008. “Nonlinear ground-response analysis of Turkey flat shallow stiff-soil site to strong ground motion.” Bull. Seismol. Soc. Am. 98 (1): 331–343. https://doi.org/10.1785/0120070009.
Kwok, A. O., J. P. Stewart, Y. M. A. Hashash, N. Matasovic, R. Pyke, Z. Wang, and Z. Yang. 2007. “Use of exact solutions of wave propagation problems to guide implementation of nonlinear seismic ground response analysis procedures.” J. Geotech. Geoenviron. Eng. 133 (11): 1385–1398. https://doi.org/10.1061/(ASCE)1090-0241(2007)133:11(1385).
Lee, C. P., Y. B. Tsai, and K. L. Wen. 2006. “Analysis of nonlinear site response using the LSST down hole accelerometer array data.” Soil Dyn. Earthquake Eng. 26 (5): 435–460. https://doi.org/10.1016/j.soildyn.2005.10.005.
Li, G., R. Motamed, and S. Dickenson. 2018. “Evaluation of one-dimensional multi-directional site response analyses using geotechnical down hole array data in California and Japan.” Earthquake Spectra 34 (1): 349–376. https://doi.org/10.1193/010617EQS005M.
Li, W., and D. Assimaki. 2010. “Site and motion-dependent parametric uncertainty of site-response analyses in earthquake simulations.” Bull. Seismol. Soc. Am. 100 (3): 954–968. https://doi.org/10.1785/0120090030.
Lin, P. S., B. S. J. Chiou, N. A. Abrahamson, M. Walling, C. T. Lee, and C. T. Cheng. 2011. “Repeatable source, site, and path effects on the standard deviation for ground-motion prediction.” Bull. Seismol. Soc. Am. 101 (5): 2281–2295. https://doi.org/10.1785/0120090312.
McGuire, R. K. 2004. Seismic hazard and risk analysis. Oakland, CA: Earthquake Engineering Research Institute.
McGuire, R. K., W. J. Silva, and C. J. Costantino. 2001. Technical basis for revision of regulatory guidance on design ground motions: Hazard- and risk-consistent ground motion spectra guidelines. Washington, DC: Division of Engineering Technology.
Menq, F. Y. 2003. “Dynamic properties of sandy and gravelly soils.” Ph.D. thesis, Dept. of Civil Engineering, Univ. of Texas.
Passeri, F. 2019. “Development of an advanced geostatistical model for shear wave velocity profiles to manage uncertainties and variabilities in ground response analyses.” Ph.D. dissertation, Dept. of Civil and Environmental Engineering, Politecnico di Torino.
Passeri, F., S. Foti, B. R. Cox, and A. Rodriguez-Marek. 2019. “Influence of epistemic uncertainty in shear wave velocity on seismic ground response analyses.” Earthquake Spectra 35 (2): 929–954. https://doi.org/10.1193/011018EQS005M.
Pilz, M., and F. Cotton. 2019. “Does the 1D assumption hold for site response analysis? A study of seismic site responses and implication for ground motion assessment using KiK-net strong-motion data.” Earthquake Spectra 35 (2): 883–905. https://doi.org/10.1193/050718EQS113M.
Pinheiro, J., D. Bates, S. DebRoy, and D. Sarkar. 2019. NLME: Linear and nonlinear mixed effects models. Vienna, Austria: R Foundation for Statistical Computing.
Rathje, E. M., A. R. Kottke, and W. L. Trent. 2010. “Influence of input motion and site property variabilities on seismic site response analysis.” J. Geotech. Geoenviron. Eng. 136 (4): 607–619. https://doi.org/10.1061/(ASCE)GT.1943-5606.0000255.
R Core Team. 2019. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
Régnier, J., L. F. Bonilla, E. Bertrand, and J. F. Semblat. 2014. “Influence of the VS profiles beyond 30 m depth on linear site effects: Assessment from the KiK-net data.” Bull. Seismol. Soc. Am. 104 (5): 2337–2348. https://doi.org/10.1785/0120140018.
Renault, P., S. Heuberger, and N. A. Abrahamson. 2010. “PEGASOS refinement project: An improved PSHA for Swiss nuclear power plants.” In Proc., 14th European Conf. of Earthquake Engineering, 1–10. Istanbul, Turkey: European Association of Earthquake Engineering.
Rodriguez-Castellanos, A., F. J. Sánchez-Sesma, F. Luzon, and R. Martin. 2006. “Multiple scattering of elastic waves by subsurface fractures and cavities.” Bull. Seismol. Soc. Am. 96 (4): 1359–1374. https://doi.org/10.1785/0120040138.
Rodriguez-Marek, A., J. Bommer, R. R. Youngs, M. Crespo, P. Stafford, and M. Bahrampouri. 2020. “Capturing epistemic uncertainty in site response.” Earthquake Spectra.
Rodriguez-Marek, A., F. Cotton, N. A. Abrahamson, S. Akkar, L. Al Atik, B. Edwards, G. A. Montalva, and H. M. Dawood. 2013. “A model for single-station standard deviation using data from various tectonic regions.” Bull. Seismol. Soc. Am. 103 (6): 3149–3163. https://doi.org/10.1785/0120130030.
Rodriguez-Marek, A., E. M. Rathje, J. J. Bommer, F. Scherbaum, and P. J. Stafford. 2014. “Application of single-station sigma and site response characterization in a probabilistic seismic hazard analysis for a new nuclear site.” Bull. Seismol. Soc. Am. 104 (4): 1601–1619. https://doi.org/10.1785/0120130196.
Sandikkaya, M. A., S. Akkar, and P. Y. Bard. 2013. “A nonlinear site-amplification model for the next pan-European ground-motion prediction equations.” Bull. Seismol. Soc. Am. 103 (1): 19–32. https://doi.org/10.1785/0120120008.
Schnabel, P. B. 1973. “Effects of local geology and distance from source on earthquake ground motions.” Ph.D. dissertation, Dept. of Civil Engineering, Univ. of California.
Seyhan, E., and J. P. Stewart. 2014. “Semi-empirical nonlinear site amplification from NGA-West2 data and simulations.” Earthquake Spectra 30 (3): 1241–1256. https://doi.org/10.1193/063013EQS181M.
Stewart, J. P., K. Afshari, and C. A. Goulet. 2017. “Non-ergodic site response in seismic hazard analysis.” Earthquake Spectra 33 (4): 1385–1414. https://doi.org/10.1193/081716eqs135m.
Stewart, J. P., K. Afshari, and Y. M. A. Hashash. 2014. Guidelines for performing hazard-consistent one-dimensional ground response analysis for ground motion prediction. Berkeley, CA: Pacific Earthquake Engineering Research Center, Univ. of California, Berkeley.
Stewart, J. P., G. A. Parker, G. M. Atkinson, D. M. Boore, Y. M. A. Hashash, and W. J. Silva. 2020. “Ergodic site amplification model for central and eastern North America.” Earthquake Spectra 36: 42–68. https://doi.org/10.1177/8755293019878185.
Stewart, J. P., P. Wang, D. P. Teague, and A. Vecchietti. 2019. “Applications of non-ergodic site response in ground motion modeling.” In Proc. 7th Int. Conf. Earthquake Geotechnical Engineering. Rome: Associazione Geotecnica Italiana.
Tao, Y., and E. M. Rathje. 2019. “Insights into modeling small-strain site response derived from down hole array data.” J. Geotech. Geoenviron. Eng. 145 (7): 04019023. https://doi.org/10.1061/(ASCE)GT.1943-5606.0002048.
Tao, Y., and E. M. Rathje. 2020a. “Taxonomy for evaluating the site-specific applicability of one-dimensional ground response analysis.” Soil Dyn. Earthquake Eng. 128 (Jan): 105865. https://doi.org/10.1016/j.soildyn.2019.105865.
Tao, Y., and E. M. Rathje. 2020b. “The importance of distinguishing pseudoresonances and outcrop resonances in down hole array data.” Bull. Seismol. Soc. Am. 110 (1): 288–294. https://doi.org/10.1785/0120190097.
Thompson, E. M., L. G. Baise, Y. Tanaka, and R. E. Kayen. 2012. “A taxonomy of site response complexity.” Soil Dyn. Earthquake Eng. 41 (Oct): 32–43. https://doi.org/10.1016/j.soildyn.2012.04.005.
Toro, G. R. 1995. Probabilistic models of site velocity profiles for generic and site-specific ground motion amplification studies. Upton, NY: Brookhaven National Laboratory.
Toro, G. R., N. A. Abrahamson, and J. F. Schneider. 1997. “Model of strong ground motions from earthquakes in Central and Eastern North America: Best estimates and uncertainties.” Seismol. Res. Lett. 68 (1): 41–57. https://doi.org/10.1785/gssrl.68.1.41.
Tsai, C. C., and Y. M. A. Hashash. 2009. “Learning of dynamic soil behavior from down hole arrays.” J. Geotech. Geoenviron. Eng. 135 (6): 745–757. https://doi.org/10.1061/(ASCE)GT.1943-5606.0000050.
Yee, E., J. P. Stewart, and K. Tokimatsu. 2013. “Elastic and large-strain nonlinear seismic site response from analysis of vertical array recordings.” J. Geotech. Geoenviron. Eng. 139 (10): 1789–1801. https://doi.org/10.1061/(ASCE)GT.1943-5606.0000900.
Zalachoris, G., and E. M. Rathje. 2015. “Evaluation of one-dimensional site response techniques using borehole arrays.” J. Geotech. Geoenviron. Eng. 141 (12): 04015053. https://doi.org/10.1061/(ASCE)GT.1943-5606.0001366.

Information & Authors

Information

Published In

Go to Journal of Geotechnical and Geoenvironmental Engineering
Journal of Geotechnical and Geoenvironmental Engineering
Volume 147Issue 1January 2021

History

Received: Nov 2, 2019
Accepted: Jul 14, 2020
Published online: Oct 19, 2020
Published in print: Jan 1, 2021
Discussion open until: Mar 19, 2021

Permissions

Request permissions for this article.

Authors

Affiliations

Professor, Dept. of Civil and Environmental Engineering, Univ. of California, Los Angeles, Los Angeles, CA 90095 (corresponding author). ORCID: https://orcid.org/0000-0003-3602-3629. Email: [email protected]
Senior Earthquake Engineer, Karen Clark and Co., 116 Huntington Ave., Boston, MA 02116. ORCID: https://orcid.org/0000-0001-9219-2158. Email: [email protected]

Metrics & Citations

Metrics

Citations

Download citation

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

Cited by

View Options

Get Access

Access content

Please select your options to get access

Log in/Register Log in via your institution (Shibboleth)
ASCE Members: Please log in to see member pricing

Purchase

Save for later Information on ASCE Library Cards
ASCE Library Cards let you download journal articles, proceedings papers, and available book chapters across the entire ASCE Library platform. ASCE Library Cards remain active for 24 months or until all downloads are used. Note: This content will be debited as one download at time of checkout.

Terms of Use: ASCE Library Cards are for individual, personal use only. Reselling, republishing, or forwarding the materials to libraries or reading rooms is prohibited.
ASCE Library Card (5 downloads)
$105.00
Add to cart
ASCE Library Card (20 downloads)
$280.00
Add to cart
Buy Single Article
$35.00
Add to cart

Get Access

Access content

Please select your options to get access

Log in/Register Log in via your institution (Shibboleth)
ASCE Members: Please log in to see member pricing

Purchase

Save for later Information on ASCE Library Cards
ASCE Library Cards let you download journal articles, proceedings papers, and available book chapters across the entire ASCE Library platform. ASCE Library Cards remain active for 24 months or until all downloads are used. Note: This content will be debited as one download at time of checkout.

Terms of Use: ASCE Library Cards are for individual, personal use only. Reselling, republishing, or forwarding the materials to libraries or reading rooms is prohibited.
ASCE Library Card (5 downloads)
$105.00
Add to cart
ASCE Library Card (20 downloads)
$280.00
Add to cart
Buy Single Article
$35.00
Add to cart

Media

Figures

Other

Tables

Share

Share

Copy the content Link

Share with email

Email a colleague

Share