Modeling the Mechanical Behavior of Lung Tissue at the Microlevel
Publication: Journal of Engineering Mechanics
Volume 135, Issue 5
Abstract
This paper is concerned with the development of a computational model of pulmonary alveoli against the background of ventilator-induced lung injuries. In order to quantify mechanical stimulation of alveolar tissue during artificial respiration, a detailed constitutive model of alveolar septa and an approach to consider interfacial phenomena is needed. For that purpose, a polyconvex hyperelastic material model formerly developed for arteries is adopted for pulmonary alveoli. Information about tissue morphology is inherently integrated into the constitutive model, therefore, establishing a connection between structure and function of the different septal constituents. Structural and interfacial dynamics are directly coupled at the alveolar surface. In order to take into account the complex behavior of surface active agents covering alveoli, a constitutive model considering dynamical changes of surface energy is employed.
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Acknowledgments
Support by the German Science Foundation/Deutsche Forschungsgemeinschaft (DFG)DFG is gratefully acknowledged.
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Information & Authors
Information
Published In
Journal of Engineering Mechanics
Volume 135 • Issue 5 • May 2009
Pages: 434 - 438
Copyright
© 2009 ASCE.
History
Received: Sep 27, 2007
Accepted: Feb 8, 2008
Published online: May 1, 2009
Published in print: May 2009
Notes
Note. Associate Editor: Christian Hellmich
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