Review of the Process Optimization in Microbial Fuel Cell using Design of Experiment Methodology
Publication: Journal of Hazardous, Toxic, and Radioactive Waste
Volume 24, Issue 3
Abstract
In the last couple of decades, microbial fuel cells (MFCs) have gained importance because of its ability to generate electricity from renewable and carbon-neutral energy sources, such as wastewater. The occurrence of simultaneous biological and electrochemical processes to facilitate the electron transfer mechanism increases the process complexity. Considerable experimental and modeling techniques have been carried out to identify the different processes involved and their relative effect on electricity generation to improve the performance of the MFCs for practical applications. Among the various statistical modeling approaches, the design of experiments (DoE) is used as a robust tool to determine the relationship between variables influencing the performance of the MFCs and to perform optimization of configuration and operation of the MFCs. It has several advantages over the one-factor-at-a-time (OFAT) methodology, in terms of time and resource management as well as obtaining relevant information. This review illustrates the most popular experimental designs used in MFC-related studies. It is expected that the paper will encourage researchers to incorporate this method into their experimental studies to ensure high-quality research output.
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Acknowledgments
The grant received from the Department of Science and Technology, New Delhi, Government of India (EEQ/2016/000820) is duly acknowledged.
References
Aghababaie, M., M. Farhadian, A. Jeihanipour, and D. Biria. 2015. “Effective factors on the performance of microbial fuel cells in wastewater treatment—A review.” Environ. Technol. Rev. 4 (1): 71–89. https://doi.org/10.1080/09593330.2015.1077896.
Almatouq, A., and A. O. Babatunde. 2018. “Identifying optimized conditions for concurrent electricity production and phosphorus recovery in a mediator-less dual-chamber microbial fuel cell.” Appl. Energy 230: 122–134. https://doi.org/10.1016/j.apenergy.2018.08.108.
Al-Shehri, A. 2015. “Statistical optimization of pentachlorophenol biodegradation and electricity generation simultaneously in mediator–less air cathode microbial fuel cell.” J. Environ. Appl. Biores. 3: 6–15.
Al-Shehri, A. N., K. M. Ghanem, and S. M. Al-Garni. 2013. “Statistical optimization of medium components to enhance bioelectricity generation in microbial fuel cell.” Arabian J. Sci. Eng. 38 (1): 21–27. https://doi.org/10.1007/s13369-012-0397-9.
Alshehria, A. N. Z., K. M. Ghanem, and S. M. Al-Garni. 2016. “Application of a five-level central composite design to optimize operating conditions for electricity generation in a microbial fuel cell.” J. Taibah Univ. Sci. 10 (6): 797–804. https://doi.org/10.1016/j.jtusci.2015.01.004.
Antony, J. 2014. Design of experiments for engineers and scientists. 2nd ed. Amsterdam, Netherlands: Elsevier.
Arbianti, R., T. Utami, H. Hermansyah, D. Novitasari, E. Kristin, and I. Trisnawati. 2013. “Performance optimization of microbial fuel cell (MFC) using Lactobacillus bulgaricus.” Makara J. Technol. 17 (1): 32–38.
Bagchi, S., and M. Behera. 2019. “Methanogenesis suppression in microbial fuel cell by aluminium dosing.” Bioelectrochemistry 129: 206–210. https://doi.org/10.1016/j.bioelechem.2019.05.019.
Barrentine, L. B. 1999. An introduction to design of experiments: A simplified approach. Milwaukee: ASQ Quality.
Beg, S., S. Swain, M. Rahman, M. S. Hasnain, and S. S. Imam. 2019. “Application of design of experiments (DoE) in pharmaceutical product and process optimization.” In Pharmaceutical quality by design, edited by S. Beg, and M. S. Hasnain, 43–64. Cambridge, MA: Academic Press.
Behera, M., and M. M. Ghangrekar. 2009. “Performance of microbial fuel cell in response to change in sludge loading rate at different anodic feed pH.” Bioresour. Technol. 100 (21): 5114–5121. https://doi.org/10.1016/j.biortech.2009.05.020.
Behera, M., and M. M. Ghangrekar. 2017. “Optimization of operating conditions for maximizing power generation and organic matter removal in microbial fuel cell.” J. Environ. Eng. 143 (4): 04016090. https://doi.org/10.1061/%28ASCE%29EE.1943-7870.0001179.
Behera, M., P. S. Jana, T. T. More, and M. M. Ghangrekar. 2010. “Rice mill wastewater treatment in microbial fuel cells fabricated using proton exchange membrane and earthen pot at different pH.” Bioelectrochemistry 79 (2): 228–233. https://doi.org/10.1016/j.bioelechem.2010.06.002.
Chen, Y., J. Luo, Y. Yan, and L. Feng. 2013. “Enhanced production of short-chain fatty acid by co-fermentation of waste-activated sludge and kitchen waste under alkaline conditions and its application to microbial fuel cells.” Appl. Energy 102: 1197–1204. https://doi.org/10.1016/j.apenergy.2012.06.056.
Christwardana, M., D. Frattini, G. Accardo, S. P. Yoon, and Y. Kwon. 2018. “Optimization of glucose concentration and glucose/yeast ratio in yeast microbial fuel cell using response surface methodology approach.” J. Power Sources 402: 402–412. https://doi.org/10.1016/j.jpowsour.2018.09.068.
Durakovic, B. 2017. “Design of experiments application, concepts, examples: State of the art.” Period. Eng. Nat. Sci. 5 (3): 421–439.
ElMekawy, A., H. M. Hegab, X. Dominguez-Benetton, and D. Pant. 2013. “Internal resistance of microfluidic microbial fuel cell: Challenges and potential opportunities.” Bioresour. Technol. 142: 672–682. https://doi.org/10.1016/j.biortech.2013.05.061.
Escapa, A., R. Mateos, E. J. Martínez, and J. Blanes. 2016. “Microbial electrolysis cells: An emerging technology for wastewater treatment and energy recovery. from laboratory to pilot plant and beyond.” Renewable Sustainable Energy Rev. 55: 942–956. https://doi.org/10.1016/j.rser.2015.11.029.
Gujral, G., D. Kapoor, and M. Jaimini. 2018. “An updated review on design of experiment (DOE) in pharmaceuticals.” J. Drug Delivery Ther. 8 (3): 147–152. https://doi.org/10.22270/jddt.v8i3.1713.
Hashemi, J., and A. Samimi. 2012. “Steady-state electric power generation in upflow microbial fuel cell using the estimated time span method for bacteria growth domestic wastewater.” Biomass Bioenergy 45: 65–76. https://doi.org/10.1016/j.biombioe.2012.05.011.
Hassan, H., B. Jin, E. Donner, S. Vasileiadis, C. Saint, and S. Dai. 2018. “Microbial community and bioelectrochemical activities in MFC for degrading phenol and producing electricity: Microbial consortia could make differences.” Chem. Eng. J. 332: 647–657. https://doi.org/10.1016/j.cej.2017.09.114.
Herrero-Hernández, E., T. J. Smith, and R. Akid. 2013. “Electricity generation from wastewaters with starch as carbon source using a mediator-less microbial fuel cell.” Biosens. Bioelectron. 39 (1): 194–198. https://doi.org/10.1016/j.bios.2012.07.037.
Hosseinpour, M., M. Vossoughi, and I. Alemzadeh. 2014. “An efficient approach to cathode operational parameters optimization for microbial fuel cell using response surface methodology.” J. Environ. Health Sci. Eng. 12 (1): 33. https://doi.org/10.1186/2052-336X-12-33.
Ishii, S. I., S. Suzuki, T. M. Norden-Krichmar, A. Wu, Y. Yamanaka, K. H. Nealson, and O. Bretschger. 2013. “Identifying the microbial communities and operational conditions for optimized wastewater treatment in microbial fuel cells.” Water Res. 47 (19): 7120–7130. https://doi.org/10.1016/j.watres.2013.07.048.
Islam, M. A., H. R. Ong, B. Ethiraj, C. K. Cheng, and M. M. R. Khan. 2018. “Optimization of co-culture inoculated microbial fuel cell performance using response surface methodology.” J. Environ. Manage. 225: 242–251. https://doi.org/10.1016/j.jenvman.2018.08.002.
Jacyna, J., M. Kordalewska, and M. J. Markuszewski. 2018. “Design of experiments in metabolomics-related studies: An overview.” J. Pharm. Biomed. Anal. 164: 598–606.
Jia, Q., L. Wei, H. Han, and J. Shen. 2014. “Factors that influence the performance of a two-chamber microbial fuel cell.” Int. J. Hydrogen Energy 39 (25): 13687–13693. https://doi.org/10.1016/j.ijhydene.2014.04.023.
Kumar, P., and A. K. Mungray. 2017. “Microbial fuel cell: Optimizing pH of anolyte and catholyte by using the Taguchi method.” Environ. Prog. Sustainable Energy 36 (1): 120–128. https://doi.org/10.1002/ep.12459.
Liu, H., R. Ramnarayanan, and B. E. Logan. 2004. “Production of electricity during wastewater treatment using a single-chamber microbial fuel cell.” Environ. Sci. Technol. 38 (7): 2281–2285. https://doi.org/10.1021/es034923g.
Liu, Y., B. Zhang, C. Tian, C. Feng, Z. Wang, M. Cheng, and W. Hu. 2016. “Optimization of enhanced bioelectrical reactor with electricity from microbial fuel cells for groundwater nitrate removal.” Environ. Technol. 37 (8): 1008–1017. https://doi.org/10.1080/09593330.2015.1096962.
Logan, B. E., C. Murano, K. Scott, N. D. Gray, and I. M. Head. 2005. “Electricity generation from cysteine in a microbial fuel cell.” Water Res. 39 (5): 942–952. https://doi.org/10.1016/j.watres.2004.11.019.
Luo, S., H. Sun, Q. Ping, R. Jin, and Z. He. 2016. “A review of modeling bioelectrochemical systems: Engineering and statistical aspects.” Energies 9 (2): 111. https://doi.org/10.3390/en9020111.
Madani, S., R. Gheshlaghi, M. A. Mahdavi, M. Sobhani, and A. Elkamel. 2015. “Optimization of the performance of a double-chamber microbial fuel cell through factorial design of experiments and response surface methodology.” Fuel 150: 434–440. https://doi.org/10.1016/j.fuel.2015.02.039.
Martinez-Conesa, E. J., V. M. Ortiz-Martinez, M. J. Salar-Garcia, A. P. De Los Rios, F. J. Hernández-Fernández, L. J. Lozano, and C. Godínez. 2017. “A Box–Behnken design-based model for predicting power performance in microbial fuel cells using wastewater.” Chem. Eng. Commun. 204 (1): 97–104. https://doi.org/10.1080/00986445.2016.1236336.
Montgomery, D. C. 2017. Design and analysis of experiments. Hoboken, NJ: John Wiley & Sons.
Oliveira, V. B., M. Simões, L. F. Melo, and A. M. F. R. Pinto. 2013. “A 1D mathematical model for a microbial fuel cell.” Energy 61: 463–471. https://doi.org/10.1016/j.energy.2013.08.055.
Ortiz-Martínez, V. M., M. J. Salar-García, A. P. De Los Ríos, F. J. Hernández-Fernández, J. A. Egea, and L. J. Lozano. 2015. “Developments in microbial fuel cell modeling.” Chem. Eng. J. 271: 50–60. https://doi.org/10.1016/j.cej.2015.02.076.
Pandit, S., S. Ghosh, M. M. Ghangrekar, and D. Das. 2012. “Performance of an anion exchange membrane in association with cathodic parameters in a dual-chamber microbial fuel cell.” Int. J. Hydrogen Energy 37 (11): 9383–9392. https://doi.org/10.1016/j.ijhydene.2012.03.011.
Pisciotta, J. M., and J. J. Dolceamore Jr. 2016. “Bioelectrochemical and conventional bioremediation of environmental pollutants.” J. Microb. Biochem. Technol. 8 (4): 327–343. https://doi.org/10.4172/1948-5948.1000306.
Rahimnejad, M., A. Adhami, S. Darvari, A. Zirepour, and S. E. Oh. 2015. “Microbial fuel cell as new technology for bioelectricity generation: A review.” Alex. Eng. J. 54 (3): 745–756. https://doi.org/10.1016/j.aej.2015.03.031.
Rozendal, R. A., H. V. Hamelers, and C. J. Buisman. 2006. “Effects of membrane cation transport on pH and microbial fuel cell performance.” Environ. Sci. Technol. 40 (17): 5206–5211. https://doi.org/10.1021/es060387r.
Sadabad, H. R., and G. B. Gholikandi. 2017. “Harvesting direct electricity from municipal waste-activated sludge simultaneous with its aerobic stabilization process: Investigation and optimization.” J. Environ. Chem. Eng. 5 (1): 1174–1185. https://doi.org/10.1016/j.jece.2017.01.030.
Sajana, T. K., M. M. Ghangrekar, and A. Mitra. 2014. “Effect of operating parameters on the performance of sediment microbial fuel cell treating aquaculture water.” Aquacult. Eng. 61: 17–26. https://doi.org/10.1016/j.aquaeng.2014.05.004.
Salar-García, M. J., A. de Ramón-Fernández, V. M. Ortiz-Martínez, D. Ruiz-Fernández, and I. Ieropoulos. 2019. “Towards the optimisation of ceramic-based microbial fuel cells: A three-factor, three-level response surface analysis design.” Biochem. Eng. J. 144: 119–124. https://doi.org/10.1016/j.bej.2019.01.015.
Sedighi, M., S. A. Aljlil, M. D. Alsubei, M. Ghasemi, and M. Mohammadi. 2018. “Performance optimisation of microbial fuel cell for wastewater treatment and sustainable clean energy generation using response surface methodology.” Alex. Eng. J. 57 (4): 4243–4253. https://doi.org/10.1016/j.aej.2018.02.012.
Taguchi, G., and S. Konishi. 1987. Taguchi methods: Orthogonal arrays and linear graphs: Tools for quality engineering. Dearborn, MI: ASI.
Tartakovsky, B., and S. R. Guiot. 2006. “A comparison of air and hydrogen peroxide oxygenated microbial fuel cell reactors.” Biotechnol. Prog. 22 (1): 241–246. https://doi.org/10.1021/bp050225j.
Teng, S. X., Z. H. Tong, W. W. Li, S. G. Wang, G. P. Sheng, X. Y. Shi, and H. Q. Yu. 2010. “Electricity generation from mixed volatile fatty acids using microbial fuel cells.” Appl. Microbiol. Biotechnol. 87 (6): 2365–2372. https://doi.org/10.1007/s00253-010-2746-5.
Tye, H. 2004. “Application of statistical ‘design of experiments’ methods in drug discovery.” Drug Discovery Today 9 (11): 485–491. https://doi.org/10.1016/S1359-6446%2804%2903086-7.
Wang, X., Y. Tian, H. Liu, X. Zhao, and S. Peng. 2019. “Optimizing the performance of organics and nutrient removal in constructed wetland–microbial fuel cell systems.” Sci. Total Environ. 653: 860–871. https://doi.org/10.1016/j.scitotenv.2018.11.005.
Weissman, S. A., and N. G. Anderson. 2015. “Design of experiments (DoE) and process optimization. A review of recent publications.” Org. Process Res. Dev. 19 (11): 1605–1633. https://doi.org/10.1021/op500169m.
Xia, C., D. Zhang, W. Pedrycz, Y. Zhu, and Y. Guo. 2018. “Models for microbial fuel cells: A critical review.” J. Power Sources 373: 119–131. https://doi.org/10.1016/j.jpowsour.2017.11.001.
Yuangyai, C., and H. B. Nembhard. 2010. “Design of experiments: A key to innovation in nanotechnology.” In Emerging nanotechnologies for manufacturing, edited by W. Ahmed, and M. J. Jackson, 207–234. Waltham, MA: William Andrew.
Zhang, B., J. Zhang, Q. Yang, C. Feng, Y. Zhu, Z. Ye, and J. Ni. 2012. “Investigation and optimization of the novel UASB–MFC integrated system for sulfate removal and bioelectricity generation using the response surface methodology (RSM).” Bioresour. Technol. 124: 1–7. https://doi.org/10.1016/j.biortech.2012.08.045.
Zhang, Q., L. Zhang, H. Wang, Q. Jiang, and X. Zhu. 2018. “Simultaneous efficient removal of oxyfluorfen with electricity generation in a microbial fuel cell and its microbial community analysis.” Bioresour. Technol. 250: 658–665. https://doi.org/10.1016/j.biortech.2017.11.091.
Zhang, Y., and I. Angelidaki. 2011. “Submersible microbial fuel cell sensor for monitoring microbial activity and BOD in groundwater: Focusing on impact of anodic biofilm on sensor applicability.” Biotechnol. Bioeng. 108 (10): 2339–2347. https://doi.org/10.1002/bit.23204.
Zhang, Y., M. Liu, M. Zhou, H. Yang, L. Liang, and T. Gu. 2019. “Microbial fuel cell hybrid systems for wastewater treatment and bioenergy production: Synergistic effects, mechanisms and challenges.” Renewable Sustainable Energy Rev. 103: 13–29. https://doi.org/10.1016/j.rser.2018.12.027.
Zhang, Z., and B. Xiaofeng. 2009. “Comparison about the three central composite designs with simulation.” In 2009 International Conference on Advanced Computer Control, 163–167. Washington, DC: IEEE.
Zhao, H., and C. H. Kong. 2018. “Elimination of pyraclostrobin by simultaneous microbial degradation coupled with the Fenton process in microbial fuel cells and the microbial community.” Bioresour. Technol. 258: 227–233. https://doi.org/10.1016/j.biortech.2018.03.012.
Zinadini, S., A. A. Zinatizadeh, M. Rahimi, V. Vatanpour, and K. Bahrami. 2017. “Energy recovery and hygienic water production from wastewater using an innovative integrated microbial fuel cell–membrane separation process.” Energy 141: 1350–1362. https://doi.org/10.1016/j.energy.2017.11.057.
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Journal of Hazardous, Toxic, and Radioactive Waste
Volume 24 • Issue 3 • July 2020
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© 2020 American Society of Civil Engineers.
History
Received: Sep 6, 2019
Accepted: Dec 10, 2019
Published online: Apr 9, 2020
Published in print: Jul 1, 2020
Discussion open until: Sep 9, 2020
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