Simplified Finite-Element Model for Tissue Regeneration with Angiogenesis
Publication: Journal of Engineering Mechanics
Volume 135, Issue 5
Abstract
A simplified finite-element model for tissue regeneration is proposed. The model takes into account the sequential steps of angiogenesis (neo-vascularization) and wound closure (the actual healing of a wound). An innovation in the present study is the combination of both partially overlapping processes, yielding novel insights into the process of wound healing, such as geometry related influences, and could be used to investigate the influence of local injection of hormones that stimulate partial processes occurring during wound healing. These insights can be used to improve wound healing treatments. The models consist of nonlinearly coupled diffusion-reaction equations, in which transport of oxygen, growth factors, and epidermal cells and mitosis are taken into account.
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Acknowledgments
The writer would like to thank Dr. J. A. Adam, from the Old Dominion University in the United States of America, for having read the manuscript carefully. Further, the manuscript improved from the helpful suggestions of the referees.
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Information & Authors
Information
Published In
Journal of Engineering Mechanics
Volume 135 • Issue 5 • May 2009
Pages: 450 - 460
Copyright
© 2009 ASCE.
History
Received: Aug 22, 2007
Accepted: Mar 11, 2008
Published online: May 1, 2009
Published in print: May 2009
Notes
Note. Associate Editor: Christian Hellmich
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